RESUMO
IgG or IgM anticardiolipin antibodies were present in the sera of 67% of 33 patients with Hansen's disease, in 53% of 30 patients with tuberculosis and in 50% of 16 patients with endocarditis. Despite the high frequency of these antibodies, no patient had a history of thrombosis or abortion. Anti-denatured DNA antibodies were tested in patients with tuberculosis and patients with Hansen's disease. Only in the latter group did we observe a statistically significant association between anticardiolipin and anti-denatured DNA antibodies. Anticardiolipin binding activity, however, could not be inhibited by preincubation of sera with a variable concentration of denatured DNA. These data suggest that: a) Anticardiolipin antibodies in infectious diseases do not necessarily participate in the pathogenesis of thrombotic or obstetric complications; b) Anti-denatured DNA and anticardiolipin antibodies in the population studied do not have a cross-reaction.
Assuntos
Autoanticorpos/análise , Cardiolipinas/imunologia , Infecções/imunologia , Adolescente , Adulto , Idoso , Fatores de Coagulação Sanguínea/análise , Fatores de Coagulação Sanguínea/imunologia , Criança , DNA/imunologia , Endocardite Bacteriana/imunologia , Ensaio de Imunoadsorção Enzimática , Feminino , Humanos , Hanseníase/imunologia , Inibidor de Coagulação do Lúpus , Masculino , Pessoa de Meia-Idade , Tuberculose/imunologiaRESUMO
Three methods of evaluation were used to investigate the relationship between skin test reactions elicited by different antigens of Mycobacterium leprae. The latter were the Fernandez and Mitsuda reactions to lepromin, and that to a Soluble Protein Antigen (SPA) of M. leprae. All three methods of evaluation demonstrated some degree of relationship though not as high as would be expected. The closest correlation was between Mitsuda and SPA reactions; while Fernandez and Mitsuda, and Fernandez and SPA reactions showed more or less similar coefficients of correlation.